Brand new metabolites off alprostadil try excreted mainly from the renal, with almost ninety% of an enthusiastic given intravenous serving excreted inside the pee in 24 hours or less post-dose. The rest of the latest amount are excreted on feces. There is no proof of structure storage out of alprostadil otherwise their metabolites following intravenous management.

Scientific studies

The power of CAVERJECT try examined in guys that have a diagnosis of impotence problems on account of psychogenic, vasculogenic, neurogenic, and/otherwise blended etiology in 2 double-blind placebo controlled education (Study 1 and read dos) and in one to 6-times open-title studies (Research step three). In clinical studies (Research step 1 and study step 3), more 80% off customers educated an erection enough to possess intercourse once intracavernosal injections away from CAVERJECT.

Research step 1

A total of 153 boys with ED with a mean many years of 53 ages (diversity age) was signed up. The research had three phases: a two.5 times, randomized, double-blind, placebo-controlled crossover phase where for every single son gotten inside-workplace injections off placebo or 2.5 mcg, 5 mcg, seven.5 mcg, otherwise 10 mcg away from CAVERJECT; a two day, open-name, in-work environment dose-titration stage to recognize the latest greatest house-explore dose (aforementioned serving try recognized as an amount inducing a hardon sufficient to have gender and you may long-term ?one hour); and a good 4-day open-identity, athome phase. On double-blind placebo-managed, crossover phase, per amount regarding CAVERJECT are much more productive than placebo by logical evaluation (“full penile tightness”) by RigiScan standards (? 70% tightness for at least ten minutes); you will find no response to placebo.