Associated clinical observations and you will factors

With clinical observations of several COVID-19 patients having a marked hypoxemia disproportional to the degree of infiltrates, pulmonary vasculature endothelitis and microthrombi which were suspected clinically have now been shown to be a prominent feature of COVID-19 lung pathology . Any component of hypoxic pulmonary vasoconstriction and further exacerbation of pulmonary hypertension in this setting is best avoided. Further to this point, nocturnal drop in oxygen saturation is a well-known phenomenon , is common in patients with primary pulmonary hypertension , and has also been demonstrated in patients with pneumonia and sepsis .